UNDERSTANDING DISEASE

Acromegaly Disease

Acromegaly is caused by excess growth hormone - usually from a non-cancerous pea-sized gland called pituitary - and leads to gradual enlargement of the hands, feet, face, and soft tissues, along with serious metabolic and cardiovascular complications that require timely diagnosis and management.

Acromegaly Disease

Disease Development and Impact

Changes are typically slow and progressive over months to years, so symptoms may be subtle early on. Left untreated, acromegaly causes health problems and death through cardiovascular, metabolic, respiratory and vision complications; effective diagnosis and treatment reduce these risks and can halt or partially reverse some features.

Individuals can share their experiences

Prevalence mean age diagnosis 40-50 years old2-4

Affects men and women equally2-3

Causes and Signs & Symptoms

MORE THAN 95% are due to growth hormone secreting pituitary tumours 5

In rare occasion, non-pituitary neuroendocrine tumours that cause ectopic secretion of growth hormone releasing hormone (GHRH) which may be bronchial, pancreatic, gastrointestinal, thymic and tumours associated with Multiple endocrine neoplasia type 1 (MEN1).

Signs & Symptoms

Symptoms often develop slowly and may be missed. Watch for:

Enlarged extremities e.g. hands or feet (Ring no longer fit/changes in shoe sizes)

Facial Changes (Broader nose, protruding lower jaw, broader forehead)

Joint Pain

Headaches or vision

Lower pitch voice

Snoring or fatigue

LEARN MORE

Acromegaly Treatment

Respiratory

Skeletal and rheumatological

Neurological

Why Early Diagnosis Matters

If left untreated, acromegaly can lead to serious complications like:

High Blood Pressure

22.3% – 76.8%9

Type 2 Diabetes

18% –77%9

High Cholesterol

up to 61%9

Overweight

>40%9

LEARN MORE

Acrogemaly Treatment

Cardiovascular

Metabolic

Endocrine

Gastrointestinal Tumours

References

Welcome to P'aware

Let’s get started. Please let us know whether you are a patient seeking support or a licensed healthcare professional.

Disclaimer

This site contains medical information that is intended for Healthcare Professionals only and is not meant to substitute for the advice provided by a medical professional.
All decisions regarding patient care should be made considering the unique characteristics of the patient.

Understanding Disease

Acromegaly

Disease Management

Acromegaly

Viewing As

© 2025 Paware. All rights reserved.