Symptoms Checker8
Our recorded sessions provide valuable insights from leading healthcare professionals, researchers, and individuals who are living with Acromegaly and Cushing's Disease.
Increase in shoe size
Increase in the size of hands
(Example: patient needed to buy bigger gloves or noticed an increase in ring size and others)
Any abnormal facial features (compared to old photographs)
(Example: swollen lips and tongue, enlarged nose, protruding forehead, protruding lower jaw and others)
History of or existing Cardiac disease (including biventricular hypertrophy and diastolic or systolic dysfunction)
Carpel tunnel syndrome
Colonic polyps
Diaphoresis (excess perspiration or oily sweating)
Diffuse arthralgia (large joint pains)
Fatigue
Persistent headache
Visual field defects
New-onset or uncontrolled diabetes
New-onset or difficult-to-control hypertension
Amenorrhea
Misalignment of teeth/bite or progressive teeth spacing
Sleep apnoea syndrome (excessive snoring)
Multiple skin tags
You appear to be in good health! Your responses do not currently indicate major symptoms.
Continue to monitor your condition and maintain healthy habits. If new symptoms develop, please reassess or consult a healthcare professional.
Based on your responses, you are showing significant symptoms.
Please visit your nearest Klinik Kesihatan or healthcare provider for further diagnosis and medical advice as soon as possible.
UNDERSTANDING DISEASE
Acromegaly is caused by excess growth hormone - usually from a non-cancerous pea-sized gland called pituitary - and leads to gradual enlargement of the hands, feet, face, and soft tissues, along with serious metabolic and cardiovascular complications that require timely diagnosis and management.

Acromegaly Disease
Changes are typically slow and progressive over months to years, so symptoms may be subtle early on. Left untreated, acromegaly causes health problems and death through cardiovascular, metabolic, respiratory and vision complications; effective diagnosis and treatment reduce these risks and can halt or partially reverse some features.

Individuals can share their experiences

Prevalence mean age diagnosis 40-50 years old2-4

Affects men and women equally2-3

MORE THAN 95% are due to growth hormone secreting pituitary tumours 5
In rare occasion, non-pituitary neuroendocrine tumours that cause ectopic secretion of growth hormone releasing hormone (GHRH) which may be bronchial, pancreatic, gastrointestinal, thymic and tumours associated with Multiple endocrine neoplasia type 1 (MEN1).
Symptoms often develop slowly and may be missed. Watch for:

Enlarged extremities e.g. hands or feet (Ring no longer fit/changes in shoe sizes)

Facial Changes (Broader nose, protruding lower jaw, broader forehead)

Joint Pain

Headaches or vision

Lower pitch voice

Snoring or fatigue
LEARN MORE
Respiratory
You may suffer from sleep apnoea, and snoring. 2,15,16
Skeletal and rheumatological
You may suffer from osteoporosis, vertebral fractures, and painful bone and joint pathologies, which can reduce joint mobility and progress to true osteoarthritis. 2.15
Neurological
Carpal tunnel syndrome, most of-ten nocturnal paraesthesia ("tin-gling") can occur in the hands as a result of damage to the median nerve (in the palm of the hand). 2,16
If left untreated, acromegaly can lead to serious complications like:
High Blood Pressure

22.3% – 76.8%9
Type 2 Diabetes

18% –77%9
High Cholesterol

up to 61%9
Overweight

>40%9
LEARN MORE
Cardiovascular
You may develop arterial hypertension and or cardiomyopathy (increased size and volume of the heart) with abnormalities in cardiac contractility, sometimes severe heart valve pathologies, or heart rhythm or conduction disorders. Certain cardiac signs may be a result of arterial hyper-tension. GH acts on the muscle of the heart (myocardium), causing hypertrophy (increase in size) of muscle fibres and collagen tissue, thus increasing the size of the heart9.
Metabolic
GH increases blood glucose levels and exerts a lipolytic effect, which can lead to diabetes and disrupt the balance of fatty acids. 9
Endocrine
Excess GH can cause disorders in thyroid function, the development of multinodular thyroid goitres and hyperparathyroidism. The risk of cancer may be increased according to certain studies. 2.19
Gastrointestinal Tumours
The incidence of polyps in the colon may be higher in patients with acromegaly. 2.15
References
1. Kwon O, Song YD, Seong YK, Lee EJ, et al. Nationwide survey of acromegaly in South Korea. Clin Endocrinol (Oxf). 2013;78(4):577-852. Burton T, Le Nestour E, Neary M, Ludlam W. Incidence and prevalence of acromegaly in a large US health plan database. Pituitary. 2016;19:262-267.3. Broder M, Chang E, Cherepanov D, Neary M, Ludlam W. Incidence and prevalence of acromegaly in the United States: a claims-based analysis. Endocr Pract. 2016;22:1327-1335.4. Dal J, Feldt-Rasmussen U, Andersen M, et al. Acromegaly incidence, prevalence, complications and long-term prognosis: a nationwide cohort study. Eur J Endocrinol. 2016;175:181-190.5. Katznelson L, Laws E, Melmed S, et al. Acromegaly: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2014;99:3933-3951.6. Zarool-Hassan R, Conaglen HM, Conaglen JV, Elston MS. Symptoms and signs of acromegaly: an ongoing need to raise awareness among healthcare practitioners. J Prim Health Care. 2016;8(2):157-63. doi: 10.1071/HC15033. 7. Hong J, Ku C, Kim S, Lee E. Characteristics of acromegaly in Korea with a literature review. Endocrinol Metab (Seoul). 2013;28(3):164-168.8. 2019 Criteria to Suspect and Refer ACROMEGALY Patients from Primary Care Centre to Dedicated Endocrine Centres9. Iglesias P. Acromegaly and Cardiovascular Disease: Associated Cardiovascular Risk Factors, Cardiovascular Prognosis, and Therapeutic Impact. J Clin Med. 2025 Mar 12;14(6):190610. Baldomero G. The Prevalence of Colonic Polyps in Patients with Acromegaly: A Case-Control, Nested in a Cohort Colonoscopic Study, Endocrine Practice, Volume 23, Issue 5, 2017, 594-59911. Colao A. Systemic complications of acromegaly: epidemiology, pathogenesis, and management. Endocr Rev. 2004 Feb;25(1):102-5212. Jean Ho P. Bone mineral density of the Axial Skeleton in Acromegaly. J Nucl Med. 1992;33:1608–1612.13. Tagliafico A et al. The pathology of the ulnar nerve in acromegaly. Eur J Endocrinol. 2008 Oct;159(4):369–73

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This site contains medical information that is intended for Healthcare Professionals only and is not meant to substitute for the advice provided by a medical professional.
All decisions regarding patient care should be made considering the unique characteristics of the patient.